The 2nd International Metagenome and Microbiome Conference (IMMC 2026) builds on the success of the first conference by highlighting the integration of Artificial Intelligence (AI) with metagenome and microbiome research. The conference is a global event that brings together researchers and experts from around the world to keep pace with the latest technologies and developments in metagenome and microbiome science, with a focus on practical applications in human health, agriculture, industry, and the environment, as well as the role of Artificial Intelligence in accelerating data analysis, improving diagnostics, and enhancing innovation. The conference also provides a platform for presenting research, conducting workshops, and promoting collaboration among different sectors.